Piraeus has been the port for Athens since 482 BC. The busy harbor is filled with ferries and cruise ships making their way to the Greek Islands and other Mediterranean cities. The busy metropolis of Athens and its treasure trove of antiquities lie just a few miles from the port. Even as the reality of the modern city took hold, with its high-rise apartments, crowded sidewalks and bustling traffic, the beauty of the Acropolis, the outstanding museums, charming cafés, sidewalk markets and startling views come together in a cultural mosaic for all to enjoy.

Syros is an important island in the Cyclades, but rather off the tourist map. Just the sort of place we like. The town (named for Hermes) is the capital of the island group, and its airy Miaouli Plaza is a wonderful, palm-lined place to sit in a cafe and have a drink. The medieval Venetian village of Ano Syros crowns a hilltop nearby. Wander the narrow, cobblestone streets to the impressive 13th-century Agios Georgios church. Back in town, the Eastern Orthodox Church of the Assumption holds an icon by the Greek painter known as El Greco. A small archeological museum has some very fine Cycladic figures, and the Ermoupolis Industrial Museum recounts the island legacy of shipbuilding and other occupations.

This Turkish town is located on the site of ancient Telmessos, the capital of the Lycians. Their rock-cut tombs honeycomb the mountainsides, especially the impressive tomb of Amyntas from around 350 BCE. Manmade sites include more tombs at nearby Pinara and the ghost town of Kayakoy. Natural splendors include the dramatic gorge of Saklikent.

Today Bodrum is a picturesque yacht harbor filled with traditional wood-varnished sailboats, charming outdoor cafes and streets bursting with small shops selling carpets, leatherwear, jewelry and local artwork. In antiquity, it was the site of ancient Halicarnassus. Under King Mausolus, the city prospered, and in death, the king left the city its most enduring legacy, his majestic tomb, from which we derive the term "mausoleum." Only its massive foundations remain today but it was the largest tomb ever built by the Greeks and one of the Seven Wonders of the Ancient World. Models on the site recreate its form for visitors. Alexander the Great attacked the city in 334 BC, leveling all but the Mausoleum, which was later destroyed by an earthquake. When the Knights of St. John lost their castle in Smyrna in 1402, they came here. Finding the mausoleum in ruins, they used the stone to construct the Castle of St. Peter, which proudly stood sentinel to the city. Together with their fortifications on Kos and Rhodes, the Knights dominated the southeastern Aegean, running a hospital for passing pilgrims and ruling the seas as privateers in swift vessels. They remained until 1523, when Ottoman ruler, Suleyman the Magnificent, conquered Rhodes and the Knights' position became untenable. The castle still dominates the harbor and houses an archeological museum.

"Thira, the Wild Island" and "Kalliste, the Fairest One" - all terms of endearment for this seductive, volcanic Greek island in the Sea of Crete. Extraordinary for its black sand beaches and sheer limestone cliffs, Santorini also showcases remnants of the Phoenician, Spartan and Minoan cultures, which fell under the island's spell - an unvarying, irresistible lure that continues to this day. Fira, the picturesque, pedestrian-only capital, is reached from the seaport via a short cable car ride that offers thrilling views as you ascend.

Nicknamed “The Isle of the Aromas”, Spetsai is a delight to all of the senses. The island’s historic old town is a yachtsman’s paradise, boasting a stunning harbor, quaint shops and some of the finest restaurants in the Saronic Gulf. The rest of the island is relatively unpopulated and is ringed by a single road, along which you can travel in a horse-drawn carriage. As you pass by quiet, rolling hills, be sure to pause at one of the many quiet coves along the way to refresh yourself with a dip into the cerulean waters.

Piraeus has been the port for Athens since 482 BC. The busy harbor is filled with ferries and cruise ships making their way to the Greek Islands and other Mediterranean cities. The busy metropolis of Athens and its treasure trove of antiquities lie just a few miles from the port. Even as the reality of the modern city took hold, with its high-rise apartments, crowded sidewalks and bustling traffic, the beauty of the Acropolis, the outstanding museums, charming cafés, sidewalk markets and startling views come together in a cultural mosaic for all to enjoy.

Deserted for centuries because of constant raids by pirates and the Turks, this tiny arid island was first settled in 1088 when the Emperor of Constantinople made it a gift to the monk Christodoulos Latrnos so that he could establish a monastery in honor of St. John the Divine on the site. Patmos has been a place of scholarship and religious enlightenment ever since. Today this modern pilgrimage site is a quiet respite from the tourist havens many other Greek isles have become.

This charming village of white houses climbing up the slopes is beautifully situated on the sparkling Gulf of Mirabello. The attractive Venetian harbor is surrounded by restaurants, outdoor cafes and clusters of shops selling everything from necessities to souvenirs. The ship docks in the center of town, and you are able to wander at will and enjoy the atmosphere of Crete's foremost resort.

Kusadasi, which means "bird island," is set in a superb gulf known for its sparkling water, broad sandy beaches and large marina. The city has managed to retain a certain earthiness while doing a brisk trade in Turkish carpets and leather goods to visitors. The town's old quarter is a picturesque maze of winding streets and houses adorned with flowers and birdcages. In the center stands a 17th-century caravanserai, now converted into a hotel. The resort is also gateway to important sites of archaeological and religious interest.

The quintessential Greek island of Mykonos is marked by whitewashed houses, domed churches, imposing windmills, and a labyrinth of winding streets designed to disorient pirates. Everywhere there is a dash of bright, bold blue - doors, shutters and window frames, sea and sky. The harbor bustles with colorful fishing boats, vendors selling fish and locals gathered with visitors in the casual seaside cafes. The port even comes with two beloved mascots, the pelicans Petros and Irini.

This small island is the westernmost of the Northern Sporades group in the Aegean Sea. It is best known for its beaches, of which the island boasts 60 beaches along its 44 km coastline. These include the nearly legendary Kokounaries beach, Banana beach and Lalaria beach with its picturesque rock arch, which is accessible only by small boats. Skiathos town curves around a pretty harbor and has a lively nightlife during the tourist season. The campanile of the Panaghia Limnia church, built in 1837, rises above pine trees on a hill atop the town. A few miles away through the island’s handsome pine forests is the Evangelistria Monastery, only entered through an imposing stone gateway.

This tiny island 12 miles off the Turkish coast embodies the ideal of the “hidden gem.” Its harbor is dominated by a sprawling crenelated fortress with Byzantine, Venetian, Genoese and Ottoman provenance. Its compact town invites visitors to explore winding cobblestone streets with no other objective than to immerse themselves in the antique atmosphere. There is no compelling attraction here other than the picturesque, but unpretentious charm of a quiet, unspoiled haven. Its small museum is the creation of a loving amateur, Hakan Guruney, who often personally leads visitors through his collection of objects and memorabilia recollecting his island’s, and in many ways his nation’s history. Much of the island’s fifteen square miles is dedicated to vineyards producing both red and white varietals. Ayazma beach offers clear water, although freshwater springs keep the water chilly even in the summer heat. At the peninsular Polente Feneri, a white lighthouse is guarded by a picket of modern, three-bladed windmills. Local flavors worth tasting are red poppy syrup and a luscious tomato jam you won’t find anywhere else.

Spanning Europe and Asia, exotic Istanbul is one of the world's most fascinating cities. Domes and minarets enhance the skyline. In the old Stamboul area, traces remain of every city built since the community was established over 600 years before Christ. Once Rome's eastern capital, Istanbul was also the center of the huge Ottoman Empire. Landmarks include Hagia Sophia, once Christendom's greatest church; the Blue Mosque with its striking Iznik tiles; Topkapi Palace, containing a sultan's ransom of treasures; Chora Church with its Byzantine mosaics; and the Grand Bazaar, the ultimate shopping experience.